Three dimensional autologous chondrocyte transplantation with a biphasic matrix
Autologous chondrocyte transplantation (ACT) has never been easier: the patient's own cells, distributed three dimensionally on a collagen matrix with a biphasic structure, can now be implanted into the defect via miniarthrotomy - in only 45 minutes!
ACT is an innovative treatment for isolatedfull thickness articular cartilage defects, and is recommended as the therapy of choice for certain indications by the German Associations for Trauma Surgery (Deutsche Gesellschaft für Unfallchirurgie) and orthopaedics and orthopaedic surgery (Deutsche Gesellschaft für Orthopädie und orthopädische Chirurgie) (ref. "DGU-Mitteilungen und Nachrichten 45/2002" and "Z. Orthop. 2002 (140):132 - 137").
Three stages to success
- Harvesting the patient's chondrocytes. This can be done immediately during arthroscopic diagnosis of the defect - using the loan instrumentation provided, two 4mm² osteochondral plugs are removed from a non load-bearing area and sent to the laboratory cooled in a special nutrient solution.
- Cultivation of autologous chondrocytes from the primary culture. After the defined number of cells has been cultivated,the autologous chondrocytes are loaded into the matrix >> Novocart 3D is returned to the treating physician with an inspection protocol confirming cell quality.
- Reimplantation exactly 3 weeks after the harvesting procedure. The defect zone is prepared via miniarthrotomy, the matrix is implanted to fit perfectly into the defect and either sewn into place with a few stitches or fixed with resorbable pins. This procedure is particularly simple using the implantation instruments provided.
Aren't they all three dimensional?
There are many carrier materials for ACT. And the matrix itself is also frequently three dimensional - but is that also true of the chondrocyte distribution? The secret of the Novocart 3D matrix lies in its biphasic structure:
A sponge component with interconnecting pores arranged in columns that have been proved to allow an even, three dimensional distribution of the chondrocytes in the sponge.
A tearproof covering membrane that prevents emigration of the chondrocytes from the defect zone and at the same time ensures easy handling for the surgeon, as for example secure and uncomplicated suturing.
- Checked and certified cell quality
- The special matrix makes it possible to achieve physiological distribution of cells and simplifies implantation
- The minimally invasive operating technique lasts a maximum of 45 minutes
- Fast and uncomplicated harvesting and reimplantation procedure
- The implant is delivered exactly three weeks later, allowing you to plan with certainty
- No investment necessary - the instrumentation and transport containers are provided by Aesculap ("all inclusive")
- Special Aesculap Academy and SFA courses provide training of proven quality
- Cooperation with TETEC AG - the cartilage cell cultivation technique has been developed by orthopaedic specialists, surgeons and biologists
- A competent partner
For further information please contact your Aesculap representative or mail to
e-mail: orthopaedics [at] aesculap [dot] de