Local haemostatic agent


Lyostypt® is used for hemostasis of capillary bleeding, oozing hemorrhages, bleeding of parenchymal organs and as a supportive measure for other hemostasis techniques.


  • Efficient Hemostasis [1-3]
  • Cost efficient [2]
  • Absorbed in 3 weeks [4-6]
  • Excellent biocompatibility [6]


Control of bleeding in arterial bypass anastomosis [7]

  • Prospective, randomized clinical trial
  • Comparison of fibrillar collagen (Lyostypt®) versus oxidized regenerated cellulose (Surgicel®) [7]
  • Hemostatic effect and handling properties were rated in suture hole bleeding of peripheral arterial bypass anastomosis using PTFE graft prosthesis
  • N = 64 anastomoses (32 Lyostypt®, 32 Surgicel®)


Bleeding time of the anastomoses

Fibrillar collagen showed significantly faster hemostasis (124 ± 67 sec) compared to oxidized regenerated cellulose (416 ± 226 sec) in suture hole bleedings of arterial bypass anastomosis [2]

Fibrillar collagen stopped suture hole bleeding of the anastomoses in less than 3 minutes in over 80 % of cases. Oxidized cellulose needed more than 5 minutes to stop suture hole bleeding in most of the anastomoses performed. [2]

The product trademark “Surgicel” is a registered trademark of Johnson & Johnson.

Summary of Advantages of Lyostypt® vs Oxidized cellulose according COBBANA Trial [2]

  • Faster hemostasis than oxidized cellulose in suture hole bleedings of arterial bypass anastomosis
  • Better adhesion to tissue and surgical handling than oxidized cellulose in suture hole bleedings of arterial bypass anastomosis
  • Lower amount of material needed to stop bleeding in comparison to oxidized cellulose

[1] Santhosh Kumar MP. Local hemostatic agents in the management of bleeding in oral surgery. Asian Journal of Pharmaceutical and Clinical Research. 2016;9:3.
[2] Qerimi B, Baumann P, Husing J, Knaebel HP, Schumacher H. Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial. Am J Surg. 2013;205(6):636-41.
[3] Fontana T, Silvestri V, Falco N, Venturelli P, Licari L, De Marco P, Gulotta E, Gulotta L, Cocorullo G. Fibrin sealant agents: clinical application of Tachosil® in abdominal surgery. Six years experience in an emergency surgery department and review of the literature. Il Giornale di chirurgia. 2018;39(5):326-330.
[4] [Data on file] Weber. Summary of animal studies to test three different hemostatic devices, which are used to stop severe liver bleeding (2006).
[5] [Data on file] Weber. Research program testing hemostatic compress material (Sangustop) in a functionality study (Hemostasis of severe liver bleedings) (2007).
[6] Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-33.
[7] Baumann P et al. A randomized controlled, prospective trial to evaluate the haemostatic effect of Lyostypt® versus Surgicel® in arterial bypass anastomosis: ‘Cobbana‘ Trial. Trials. 2009;10:91.

Related Documents

Description Document Link
Lyostypt® Brochure
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