Your choice in hemostasis


Sangustop® is specially indicated for local hemostasis of bleeding of parenchymal organs and diffuse oozing hemorrhages and as a supportive measure for other techniques of hemostasis.


  • Efficient Hemostasis [1-4]
  • Cost efficient [2]
  • Absorbed in 3 weeks [5-7]
  • Excellent biocompatibility [7]
  • Can be easily used in open and minimally invasive surgery [3]

Esscaliver Trial

Comparison of the Efficacy and Safety of Sangustop® as Haemostatic Agent Versus a Carrier- Bound Fibrin Sealant During Liver Resection (TachoSil®) [3]

  • Prospective, randomized, multicenter, non inferiority study
  • Evaluation of the haemostatic effect (after 3, 5 and 10 minutes) and the safety of the collagen haemostatic agent Sangustop®  compared to a carrierbound fibrin sealant  TachoSil®) during liver resection
  • N = 127 patients (62 Sangustop®, 65 TachoSil®)



Percentage of patients (%) where haemostasis has been achieved.

Sangustop® has shown the same effectiveness and safety compared to the carrier-bound fibrin sealant (TachoSil®). In addition it is a cost-effective hemostat, (2) that offers an easy handling in open surgery and MIS procedures. (3)

The product trademark “TachoSil” is a registered trademark of Takeda Pharmaceutical Company Limited.


[1] Santhosh Kumar MP. Local hemostatic agents in the management of bleeding in oral surgery. Asian Journal of Pharmaceutical and Clinical Research. 2016;9:3.
[2] Qerimi B, Baumann P, Husing J, Knaebel HP, Schumacher H. Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial. Am J Surg. 2013;205(6):636-41.
[3] Moench C, Mihaljevic AL, Hermanutz V, Thasler WE, Suna K, Diener MK, Seehofer D, Mischinger HJ, Jansen-Winkeln B, Knaebel HP, Bechstein WO. Randomized controlled multicenter trial on the effectiveness of the collagen hemostat Sangustop compared with a carrier-bound fibrin sealant during liver resection (ESSCALIVER study, NCT00918619). Langenbecks Arch Surg. 2014;399:725-33.
[4] Fontana T, Silvestri V, Falco N, Venturelli P, Licari L, De Marco P, Gulotta E, Gulotta L, Cocorullo G. Fibrin sealant agents: clinical application of Tachosil® in abdominal surgery. Six years experience in an emergency surgery department and review of the literature. Il Giornale di chirurgia. 2018;39(5):326-330.
[5] [Data on file] Weber. Summary of animal studies to test three different hemostatic devices, which are used to stop severe liver bleeding (2006).
[6] [Data on file] Weber. Research program testing hemostatic compress material (Sangustop) in a functionality study (Hemostasis of severe liver bleedings) (2007).
[7] Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-33.

Related Documents

Description Document Link
Sangustop® Brochure
pdf (389.4 KB)