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Antibacterial wash before surgery and in ICU

Against MRSA* and other microorganisms

Numerous studies confirm that infections due to multi-drug-resistant organisms (MDRO) in the hospital are associated with high mortality,[1,2,3] lead to a two to three-fold longer period spent in hospital[4] and consequently involve higher directly attributable costs for diagnostics and therapy.[5]

staphylococcus bacteria macro view

Universal decolonization

Antibacterial whole-body wash before surgery

Elderly man in front of mirror in privat bath room performing hear and head decolonization

We know that there have been different approaches over time: First decolonization strategies focused on targeted decolonization for secondary prevention in those with recurrent episodes of Staphylococcus aureus disease. Then strategies changed to targeted decolonization for primary prevention by screening all patients for MRSA directly prior to surgery. Ultimately, universal decolonization for primary prevention has now moved strategically to the forefront.[10] 

Intended benefits from universal decolonization:

  • Reduction of antibiotic treatments
  • Reduction of Staphylococcus aureus related infections
  • Reduction of healthcare-associated infections (HAIs)
  • Reduction of surgical site infections (SSI) within a bundled strategy 
  • Cost saving in comparison to targeted decolonization
  • Higher efficacy than screening-based or targeted decolonization
  • Higher acceptance by patients and their relatives
  • Universal decolonization can be performed by patients in their own homes


Engaging your patients for patient safety

Universal decolonization can be an effective measure within a bundled strategy against surgical site infections (SSI) and hospital-acquired infections in general.[11] At the same time, it is intended to save costs compared to the targeted decolonization often practiced in hospitals.[11]
Whole-body decolonization can be done by patients themselves as a preventive measure before elective surgery. But most of your patients probably aren’t aware that they can contribute to their own protection. Maybe they don’t know that they can prepare for surgery with an antibacterial whole-body decolonization intended to reduce infections.

Doctor in consultation with patients sitting in office

Whole-body decolonization in hospital

Antibacterial wash in ICU or on inpatients

Many people that have been admitted to the hospital are not able to take care of their hygiene themselves, as they are patients in the ICU or unable to move sufficiently even if they are on a regular ward. Many of them have a weakened immune system anyway and are therefore all the more dependent on protection against germs. Unfortunately, studies show that up to 30% of patients in intensive care can be affected by health care-associated infections.[13]
Additionally, being in contact with many people in a hospital environment everyday requires prevention and protection, for all involved - including yourself.

Patient in hospital bed. Nurse decolonizes the patient's upper arm with a cloth .

Our solution

Prontoderm®, a holistic concept for whole body decolonization

Prontoderm product range

Get in touch with our experts.

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*Methicillin-resistant Staphylococcus aureus

  1. Samreen, Ahmad I, Malak HA, Abulreesh HH. Antimikrobielle Umweltresistenz und ihre Treiber: eine potenzielle Gefahr für die öffentliche Gesundheit. J Glob Antimicrob Resist. 2021 Dez;27:101-111. doi: 10,1016/j.jgar.2021.08.001. Epub 2021 25. August. PMID: 34454098.
  2. Pires D, de Kraker MEA, Tartari E, Abbas M, Pittet D. ‘Fight antibiotic resistance—it’s in your hands’: call from the World Health Organization for 5th May 2017. Clin Infect Dis 2017;64:1780–3. doi: 10.1093/cid/cix226.
  3. de Kraker ME, Davey PG, Grundmann H; BURDEN study group. Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe. PLoS Med. 2011 Oct;8(10):e1001104. doi: 10.1371/journal.pmed.1001104. Epub 2011 Oct 11. PMID: 22022233; PMCID: PMC3191157.
  4. Graves N, Weinhold D, Tong E, Birrell F, Doidge S, Ramritu P, Halton K, Lairson D, Whitby M. Effect of healthcare-acquired infection on length of hospital stay and cost. Infect Control Hosp Epidemiol. 2007 Mar;28(3):280-92. doi: 10.1086/512642. Epub 2007 Feb 20. PMID: 17326018.
  5. Everett BR, Sitton JT, Wilson M. Efficacy and Cost-Benefit Analysis of a Global Environmental Cleaning Algorithm on Hospital-Acquired Infection Rates. J Patient Saf. 2017 Dec;13(4):207-210. doi: 10.1097/PTS.0000000000000141. PMID: 25162207.
  6. Graveto JMGDN, Rebola RIF, Fernandes EA, Costa PJDS. Hand hygiene: nurses' adherence after training. Rev Bras Enferm. 2018 May;71(3):1189-1193. Portuguese, English. doi: 10.1590/0034-7167-2017-0239. PMID: 29924172.
  7. Stewart S, Robertson C, Pan J, Kennedy S, Dancer S, Haahr L, Manoukian S, Mason H, Kavanagh K, Cook B, Reilly J. Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning. J Hosp Infect. 2021 Aug;114:10-22. doi: 10.1016/j.jhin.2021.03.031. PMID: 34301392.
  8. Huang SS, Singh R, McKinnell JA, Park S, Gombosev A, Eells SJ, Gillen DL, Kim D, Rashid S, Macias-Gil R, Bolaris MA, Tjoa T, Cao C, Hong SS, Lequieu J, Cui E, Chang J, He J, Evans K, Peterson E, Simpson G, Robinson P, Choi C, Bailey CC Jr, Leo JD, Amin A, Goldmann D, Jernigan JA, Platt R, Septimus E, Weinstein RA, Hayden MK, Miller LG; Project CLEAR Trial. Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers. N Engl J Med. 2019 Feb 14;380(7):638-650. doi: 10.1056/NEJMoa1716771. PMID: 30763195; PMCID: PMC6475519.
  9. Kavanagh KT, Calderon LE, Saman DM, Abusalem SK. The use of surveillance and preventative measures for methicillin-resistant staphylococcus aureus infections in surgical patients. Antimicrob Resist Infect Control. 2014 May 14;3:18. doi: 10.1186/2047-2994-3-18. PMID: 24847437; PMCID: PMC4028005.
  10. Miller LG, McKinnell JA, Singh RD, Gussin GM, Kleinman K, Saavedra R, Mendez J, Catuna TD, Felix J, Chang J, Heim L, Franco R, Tjoa T, Stone ND, Steinberg K, Beecham N, Montgomery J, Walters D, Park S, Tam S, Gohil SK, Robinson PA, Estevez M, Lewis B, Shimabukuro JA, Tchakalian G, Miner A, Torres C, Evans KD, Bittencourt CE, He J, Lee E, Nedelcu C, Lu J, Agrawal S, Sturdevant SG, Peterson E, Huang SS. Decolonization in Nursing Homes to Prevent Infection and Hospitalization. N Engl J Med. 2023 Nov 9;389(19):1766-1777. doi: 10.1056/NEJMoa2215254. Epub 2023 Oct 10. PMID: 37815935.
  11. Prävention postoperativer Wundinfektionen  Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Apr;61(4):448-473. German. doi: 10.1007/s00103-018-2706-2. PMID:29589090
  12. Huang SS, Septimus E, Avery TR, Lee GM, Hickok J, Weinstein RA, Moody J, Hayden MK, Perlin JB, Platt R, Ray GT. Cost savings of universal decolonization to prevent intensive care unit infection: implications of the REDUCE MRSA trial. Infect Control Hosp Epidemiol. 2014 Oct;35 Suppl 3:S23-31. doi: 10.1086/677819. PMID:25222894.
  13. WHO. Global report on infection prevention and control. Geneva: World Health Organization; 2022.
  14. Reddersen K, Wiegand C, Elsner P, Hipler UC. Three-dimensional human skin model infected with Staphylococcus aureus as a tool for evaluation of bioactivity and biocompatibility of antiseptics. Int J Antimicrob Agents. 2019 Sep;54(3):283-291. doi: 10.1016/j.ijantimicag.2019.06.022. Epub 2019 Jul 3. PMID: 31279155.
  15. [15] Kaehn K. Polihexanide: a safe and highly effective biocide. Skin Pharmacol Physiol. 2010;23 Suppl:7-16. doi:10.1159/000318237
  16. [16] Müller G, Kramer A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother. 2008 Jun;61(6):1281-7. doi: 10.1093/jac/dkn125. Epub 2008 Mar 25. PMID: 18364400.
  17. [17] Wandhoff B, Schröder C, Nöth U, Krause R, Schmidt B, David S, Scheller EE, Jahn F, Behnke M, Gastmeier P, Kramer TS. Efficacy of universal preoperative decolonization with Polyhexanide in primary joint arthroplasty on surgical site infections. A multicenter before-and after-study. Antimicrob Resist Infect Control. 2020 Nov 30;9(1):188. doi: 10.1186/s13756-020-00852-0. PMID: 33256845; PMCID: PMC7708093."
  18. [18] Data on file #1
  19. [19] Data on file #2
  20. [20] Hirsch T, Koerber A, Jacobsen F, Dissemond J, Steinau HU, Gatermann S, Al-Benna S, Kesting M, Seipp HM, Steinstraesser L. Evaluation of toxic side effects of clinically used skin antiseptics in vitro. J Surg Res. 2010 Dec;164(2):344-50. doi: 10.1016/j.jss.2009.04.029. Epub 2009 May 18. PMID: 19726054.
  21. [21] Data on file #3 (report on request)
  22. [22] Castellà L, Casas I, Giménez M, Reina D, Sopena N, García-Quesada MJ; Clinical Working Group. Hygiene with wet wipes in bedridden patients to prevent catheter-associated urinary tract infection in cardiac surgery: A randomized controlled trial. Infect Control Hosp Epidemiol. 2023 Aug 24:1-4. doi: 10.1017/ice.2023.178. Epub ahead of print. PMID: 37615098.