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      DCB-based PCI in Multi-Vessel-Disease

      Clinical impact of drug coated balloon-based percutaneous coronary intervention in patients with multivessel coronary artery disease

      Significantly lower MACE rate in patients treated with SeQuent® Please (NEO) compared to DES
      Shin ES et al. JACC Cardiovasc Interv. 2023;16(3):292-299

      Overview

      Observational registry:

      • DCB (study device = SeQuent Please® (NEO)) in patients with MVD (2 or more coronary lesions)
      • Propensity score matched to patients receiving DES
         

      Primary endpoint:

      • MACE @24 months (cardiac death, MI, TVR, stroke, stent thrombosis and major bleeding)

      Results

      • In DCB-group 34.3 % of patients were treated with DCB-only, 65.7 % with hybrid PCI (DES+DCB) 
      • Stent-length was significantly reduced by 63.7 % in DCB-group 
      • MACE after 24 months was significantly lower in DCB-group vs. DES (3.9 % vs. 11 %; p=0.002)
      Total population:
      508 patients
      DCB-Based
      (n=254)
      DES-only
      (n=254)
      p-value
      Clinical endpoint after 24 months
      MACE3.9 % (10)11.0 % (28)0.002
      Cardiac death0.4 % (1)2.4 % (6)0.047
      MI01.2 % (3)0.082
      Stroke00.4 % (1)0.313
      ST (definite/probable)00.4 % (1)0.333
      TVR3.1 % (8)6.3 % (16)0.095
      Major bleeding0.4 % (1)2.8 % (7)0.027