Sirolimus + BHT (Butylated Hydroxy Toluol): Persistence in the vessel wall
Porcine overstretch model
Persistence of sirolimus in the vessel wall: 40% to 50% of the transferred drug until 1 month (SeQuent® SCB)
Similar efficacy to reduce intimal hyperplasia as compared to the SeQuent® Please paclitaxel-coated balloon [1]
Sirolimus + BHT
Controlled release of Sirolimus
Creation of the desired crystalline sirolimus modification [1]
Representative histological examples. Top left, Uncoated control; top right, AS. Bottom, from left to right: Vb 4, Vb 7, SeQuent® Please. AS indicates amorphous sirolimus coating; and Vb, crystalline sirolimus coating.
Drug release and drug persistence in the vessel wall
Drug transfer (Tissue concentration)
After 28 days: 40 to 50% of the initial transferred sirolimus dose are still within the arterial wall. [1]
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Representative histological examples. Top left, Uncoated control; top right, AS. Bottom, from left to right: Vb 4, Vb 7, SeQuent® Please. AS indicates amorphous sirolimus coating; and Vb, crystalline sirolimus coating.
