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Preclinical work

Sirolimus + BHT (Butylated Hydroxy Toluol): Persistence in the vessel wall

Representative histological examples. Top left, Uncoated control; top right, AS. Bottom, from left to right: Vb 4, Vb 7, SeQuent® Please. AS indicates amorphous sirolimus coating; and Vb, crystalline sirolimus coating.

Drug release and drug persistence in the vessel wall

[1] Clever et al. Circ Cardiovasc Interv. 2016 Apr;9(4):e003543.