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Wound bed preparation
According to studies(1) it is of high likelihood that biofilms are ubiquitous present in non-healing human chronic wounds. Awareness on its presence and distinct differences in phenotype are important, especially in regard of the challenges in removing and eradicating biofilms from a wound.
It is commonly agreed that wounds must not be infected and that a well vascularized wound bed, free of fibrinous material and scarring should be achieved. The concept of wound bed preparation suggested by Falanga V. in 2000 aims to achieve these targets because only a clean wound can heal.(2)
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1) Malone M, Bjarnsholt T, McBain AJ, James GA, Stoodley P, Leaper D, Tachi M, Schultz G, Swanson T, Wolcott RD. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. J Wound Care. 2017 Jan 2;26(1):20-25. doi: 10.12968/jowc.2017.26.1.20. PMID: 28103163.
2) Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen. 2000 Sep-Oct;8(5):347-52. PMID: 11115147.